There are 3 dosage strengths of ZORTRESS: 0.25 mg, 0.5 mg, and 0.75 mg tablets.
Be sure to take ZORTRESS exactly as directed by your health care provider. Always follow your transplant team’s instructions as directed, and call your doctor or transplant coordinator if you have any questions. Do NOT stop taking ZORTRESS or change your dose unless your doctor tells you to. Take ZORTRESS at the same time as your dose of cyclosporine or tacrolimus medicine. Do NOT stop taking or change your dose of cyclosporine or tacrolimus medicine unless your doctor tells you to. If your doctor changes your dose of cyclosporine, your dose of ZORTRESS may change.
TAKE ZORTRESS 2 TIMES A DAY, ABOUT 12 HOURS APART. TAKE ZORTRESS AT THE SAME TIME EVERY DAY.
Swallow ZORTRESS tablets whole with a full glass of water. Do not crush or chew ZORTRESS tablets.
You may take ZORTRESS with or without food. If you take ZORTRESS with food, always take it with food. If you take ZORTRESS without food, always take it without food.
Your doctor will do regular blood tests to check your kidney function while you take ZORTRESS. It is important that you get these tests done when your doctor tells you to. Blood tests will monitor how your kidneys are working and make sure you are getting the right dose of ZORTRESS and other transplant medications you may be on (cyclosporine or tacrolimus).
Avoid receiving any live vaccines while taking ZORTRESS. Some vaccines may not work as well while you are taking ZORTRESS.
DO NOT eat grapefruit or drink grapefruit juice at any time while taking ZORTRESS. Grapefruit may increase your blood level of ZORTRESS.
Limit the amount of time you spend in the sunlight. Avoid using tanning beds or sunlamps. People who take ZORTRESS have a higher risk of getting skin cancer. Wear protective clothing when you are in the sun and use a sunscreen with a high protection factor (SPF 30 and above). This is especially important if you have fair skin or if you have a family history of skin cancer.
Avoid becoming pregnant. Talk to your doctor if you are pregnant or plan to become pregnant. It is unknown if ZORTRESS will harm your unborn baby. Women who may become pregnant should use effective birth control (contraception) while taking ZORTRESS and for 8 weeks after stopping ZORTRESS.
What if I take too much?
Call your doctor or transplant coordinator, or go to the nearest hospital emergency room right away.
What if I miss a dose?
Call your doctor or transplant coordinator right away.
What is the most important information I should know about ZORTRESS?
ZORTRESS can cause serious side effects, including:
For kidney transplant patients only:
For heart transplant patients only:
Do not take ZORTRESS if you are allergic to everolimus (ZORTRESS/AFINITOR®) or any of the ingredients in ZORTRESS or sirolimus (Rapamune®).
Before taking ZORTRESS, tell your doctor if you have liver problems; have skin cancer or it runs in your family; have high cholesterol or triglycerides (fat in your blood); have Lapp lactase deficiency or glucose-galactose malabsorption; have any other medical conditions; are pregnant or plan to become pregnant. It is not known if ZORTRESS will harm your unborn baby. Women who may become pregnant should use effective birth control (contraception) while taking ZORTRESS and for 8 weeks after stopping ZORTRESS. Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if ZORTRESS passes into your breast milk. You and your doctor should decide if you will take ZORTRESS or breastfeed. You should not do both.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. ZORTRESS may affect the way other medicines work, and other medicines may affect how ZORTRESS works. Especially tell your doctor if you take antifungal medicine, antibiotic medicine, heart medicine, high blood pressure medicine, a medicine to lower cholesterol or triglycerides, cyclosporine (Sandimmune, Gengraf, Neoral), tuberculosis (TB) medicine, HIV medicine, St. John's Wort, or seizure (anticonvulsant) medicine.
What should I avoid while taking ZORTRESS?
What are possible side effects of ZORTRESS?ZORTRESS can cause serious side effects, including:
Your doctor should do blood and urine tests to monitor your cholesterol, triglycerides, and kidney function.
These common side effects have been reported in both kidney and liver transplant patients: nausea, swelling of the lower legs, ankles, and feet, and high blood pressure.
The most common side effects of ZORTRESS in people who have had a kidney transplant include constipation, low red blood cell count (anemia), urinary tract infection, and increased fat in the blood (cholesterol and triglycerides).
The most common side effects of ZORTRESS in people who have had a liver transplant include diarrhea, headache, fever, abdominal pain, and low white blood cells.
These are not all of the possible side effects of ZORTRESS. Tell your doctor about any side effect that bothers you or that does not go away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
What is ZORTRESS® (everolimus) Tablets?
ZORTRESS is a prescription medicine used to prevent transplant rejection (antirejection medicine) in people who have received a kidney transplant or liver transplant.
ZORTRESS is used with other medicines called cyclosporine, corticosteroids and certain other transplant medicines to prevent rejection of your transplanted kidney. ZORTRESS is used with other medicines called tacrolimus and corticosteroids to prevent rejection of your transplanted liver.
It is not known if ZORTRESS is safe and effective in transplanted organs other than the kidney and liver.
It is not known if ZORTRESS is safe and effective in children under 18 years of age.
Please click here for Important Product Information, including Boxed WARNINGS and Medication Guide.
Reference: 1. ZORTRESS [prescribing information]. East Hanover NJ: Novartis Pharmaceuticals Corp; 2015.
Gengraf is a registered trademark of AbbVie Inc.
Rapamune is a registered trademark of Pfizer Inc.